Detailed information of TA system TA260440

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 103094..103520
• Replicon: plasmid pSul1-K28074
• Accession: NZ_CP107016
• Organism: Klebsiella pneumoniae strain K30821

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: OF890_RS28610
• Protein ID: WP_001372321.1
• Coordinates: 103094..103219 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	103296..103520 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OF890_RS28580 (98492)	98492..99181	-	690	WP_000283387.1	conjugal transfer transcriptional regulator TraJ	-
OF890_RS28585 (99368)	99368..99751	-	384	WP_001151538.1	conjugal transfer relaxosome DNA-binding protein TraM	-
OF890_RS28590 (100072)	100072..100674	+	603	Protein_118	transglycosylase SLT domain-containing protein	-
OF890_RS28595 (100971)	100971..101791	-	821	Protein_119	DUF945 domain-containing protein	-
OF890_RS28600 (101901)	101901..102197	-	297	WP_001545326.1	hypothetical protein	-
OF890_RS28605 (102497)	102497..102793	+	297	Protein_121	hypothetical protein	-
OF890_RS28610 (103094)	103094..103219	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
OF890_RS28615 (103161)	103161..103310	-	150	Protein_123	plasmid maintenance protein Mok	-
- (103296)	103296..103520	-	225	NuclAT_0	-	Antitoxin
- (103296)	103296..103520	-	225	NuclAT_0	-	Antitoxin
- (103296)	103296..103520	-	225	NuclAT_0	-	Antitoxin
- (103296)	103296..103520	-	225	NuclAT_0	-	Antitoxin
OF890_RS28620 (103532)	103532..104251	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
OF890_RS28625 (104248)	104248..104682	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
OF890_RS28630 (104751)	104751..106715	-	1965	WP_001537566.1	ParB/RepB/Spo0J family partition protein	-
OF890_RS28635 (106776)	106776..107009	-	234	WP_000006003.1	DUF905 family protein	-
OF890_RS28640 (107067)	107067..107552	-	486	WP_031311812.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sul1 / aadA2 / dfrA12	senB	1..124616	124616

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T260440 WP_001372321.1 NZ_CP107016:c103219-103094 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT260440 NZ_CP107016:c103520-103296 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin