Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 732894..733669 | Replicon | chromosome |
Accession | NZ_CP107014 | ||
Organism | Klebsiella pneumoniae strain K30821 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A1Q4Q548 |
Locus tag | OF890_RS03670 | Protein ID | WP_004150910.1 |
Coordinates | 733184..733669 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | W8UEW1 |
Locus tag | OF890_RS03665 | Protein ID | WP_004150912.1 |
Coordinates | 732894..733187 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OF890_RS03645 (OF890_03645) | 728102..728704 | - | 603 | WP_062954968.1 | short chain dehydrogenase | - |
OF890_RS03650 (OF890_03650) | 728802..729713 | + | 912 | WP_004188550.1 | LysR family transcriptional regulator | - |
OF890_RS03655 (OF890_03655) | 729714..730862 | - | 1149 | WP_004150915.1 | PLP-dependent aspartate aminotransferase family protein | - |
OF890_RS03660 (OF890_03660) | 730873..732249 | - | 1377 | WP_004217775.1 | cystathionine beta-synthase | - |
OF890_RS03665 (OF890_03665) | 732894..733187 | + | 294 | WP_004150912.1 | DUF1778 domain-containing protein | Antitoxin |
OF890_RS03670 (OF890_03670) | 733184..733669 | + | 486 | WP_004150910.1 | GNAT family N-acetyltransferase | Toxin |
OF890_RS03675 (OF890_03675) | 734373..734966 | + | 594 | WP_004188553.1 | hypothetical protein | - |
OF890_RS03680 (OF890_03680) | 735063..735279 | + | 217 | Protein_723 | transposase | - |
OF890_RS03685 (OF890_03685) | 735885..736757 | + | 873 | WP_004188557.1 | ParA family protein | - |
OF890_RS03690 (OF890_03690) | 736757..737140 | + | 384 | WP_004150906.1 | hypothetical protein | - |
OF890_RS03695 (OF890_03695) | 737133..738500 | + | 1368 | WP_004150905.1 | SPI-7-type island replicative DNA helicase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 735063..735215 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17551.59 Da Isoelectric Point: 8.8818
>T260421 WP_004150910.1 NZ_CP107014:733184-733669 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
Download Length: 486 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q4Q548 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GVL4 |