Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1887756..1888416 Replicon chromosome
Accession NZ_CP107010
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name higB Uniprot ID A0A3Z1E706
Locus tag OF884_RS08920 Protein ID WP_000269841.1
Coordinates 1887756..1888109 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OF884_RS08925 Protein ID WP_023210258.1
Coordinates 1888114..1888416 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS08895 (1883825) 1883825..1884580 + 756 WP_001089671.1 multiubiquitin domain-containing protein -
OF884_RS08900 (1884555) 1884555..1885739 + 1185 WP_000078712.1 ThiF family adenylyltransferase -
OF884_RS08905 (1885733) 1885733..1886197 + 465 WP_023210260.1 DUF6527 family protein -
OF884_RS08910 (1886574) 1886574..1887041 + 468 WP_000201258.1 hypothetical protein -
OF884_RS08915 (1887041) 1887041..1887259 + 219 WP_161976074.1 cell morphology transcriptional regulator XreR2 -
OF884_RS08920 (1887756) 1887756..1888109 + 354 WP_000269841.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF884_RS08925 (1888114) 1888114..1888416 + 303 WP_023210258.1 XRE family transcriptional regulator Antitoxin
OF884_RS08930 (1888922) 1888922..1889806 + 885 WP_023210257.1 integrase domain-containing protein -
OF884_RS08935 (1890675) 1890675..1891937 - 1263 WP_000058784.1 integrase arm-type DNA-binding domain-containing protein -
OF884_RS08945 (1892275) 1892275..1893072 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1862748..1901075 38327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13477.35 Da        Isoelectric Point: 9.5699

>T260403 WP_000269841.1 NZ_CP107010:1887756-1888109 [Salmonella enterica subsp. enterica serovar Paratyphi B]
VWTIKTTDTFDRWFASLNDTDRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11012.76 Da        Isoelectric Point: 5.7316

>AT260403 WP_023210258.1 NZ_CP107010:1888114-1888416 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFAL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E706

Antitoxin

Source ID Structure

References