260146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1800235..1800737 Replicon chromosome
Accession NZ_CP106995
Organism Escherichia coli strain SY22B3

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag OFB03_RS08630 Protein ID WP_000767829.1
Coordinates 1800483..1800737 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag OFB03_RS08625 Protein ID WP_001259255.1
Coordinates 1800235..1800486 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB03_RS08600 (1795413) 1795413..1796480 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
OFB03_RS08605 (1796480) 1796480..1797550 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
OFB03_RS08610 (1797547) 1797547..1798851 - 1305 WP_000009594.1 histidinol dehydrogenase -
OFB03_RS08615 (1798857) 1798857..1799756 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
OFB03_RS08620 (1799902) 1799902..1799952 - 51 WP_001364200.1 his operon leader peptide -
OFB03_RS08625 (1800235) 1800235..1800486 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
OFB03_RS08630 (1800483) 1800483..1800737 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
OFB03_RS08635 (1800820) 1800820..1801644 + 825 WP_000754737.1 SDR family oxidoreductase -
OFB03_RS08640 (1801690) 1801690..1802619 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
OFB03_RS08645 (1802834) 1802834..1802896 + 63 WP_010723108.1 membrane protein YoeI -
OFB03_RS08650 (1802886) 1802886..1804244 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
OFB03_RS08655 (1804423) 1804423..1805481 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
OFB03_RS08660 (1805495) 1805495..1805722 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T260146 WP_000767829.1 NZ_CP106995:1800483-1800737 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT260146 WP_001259255.1 NZ_CP106995:1800235-1800486 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References