Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10185..10843 Replicon plasmid pNY13623-1
Accession NZ_CP106989
Organism Acinetobacter baumannii strain NY13623

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OC371_RS19515 Protein ID WP_000312250.1
Coordinates 10484..10843 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OC371_RS19510 Protein ID WP_001096429.1
Coordinates 10185..10484 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC371_RS19470 (OC371_19470) 5209..6489 + 1281 WP_001093570.1 hypothetical protein -
OC371_RS19475 (OC371_19475) 6594..6851 + 258 WP_000834290.1 hypothetical protein -
OC371_RS19480 (OC371_19480) 6856..7428 + 573 WP_000443897.1 hypothetical protein -
OC371_RS19485 (OC371_19485) 7404..7583 + 180 WP_000387630.1 hypothetical protein -
OC371_RS19490 (OC371_19490) 7600..8229 + 630 WP_000701003.1 hypothetical protein -
OC371_RS19495 (OC371_19495) 8269..8487 + 219 WP_001043201.1 hypothetical protein -
OC371_RS19500 (OC371_19500) 8507..9061 + 555 WP_000790084.1 hypothetical protein -
OC371_RS19505 (OC371_19505) 9111..9647 + 537 WP_000731978.1 hypothetical protein -
OC371_RS19510 (OC371_19510) 10185..10484 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
OC371_RS19515 (OC371_19515) 10484..10843 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OC371_RS19520 (OC371_19520) 11044..11610 + 567 WP_000710385.1 hypothetical protein -
OC371_RS19525 (OC371_19525) 11659..11841 + 183 WP_000373385.1 hypothetical protein -
OC371_RS19530 (OC371_19530) 11908..12606 + 699 WP_000873188.1 hypothetical protein -
OC371_RS19535 (OC371_19535) 12745..13128 + 384 WP_000654348.1 hypothetical protein -
OC371_RS19540 (OC371_19540) 13195..13953 + 759 WP_001053127.1 hypothetical protein -
OC371_RS19545 (OC371_19545) 15008..15322 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67024 67024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T260113 WP_000312250.1 NZ_CP106989:c10843-10484 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT260113 WP_001096429.1 NZ_CP106989:c10484-10185 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References