Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4035119..4035716 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag OCU08_RS19475 Protein ID WP_012542526.1
Coordinates 4035399..4035716 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCU08_RS19470 Protein ID WP_012542525.1
Coordinates 4035119..4035406 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS19440 4031029..4031277 + 249 WP_008805539.1 DUF1158 domain-containing protein -
OCU08_RS19445 4031294..4031635 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OCU08_RS19450 4031666..4032781 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
OCU08_RS19455 4032961..4033542 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
OCU08_RS19460 4033542..4033910 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
OCU08_RS19465 4034030..4034683 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
OCU08_RS19470 4035119..4035406 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
OCU08_RS19475 4035399..4035716 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCU08_RS19480 4035901..4036944 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
OCU08_RS19485 4037474..4038340 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
OCU08_RS19490 4038449..4039876 + 1428 WP_072121872.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T260101 WP_012542526.1 NZ_CP106964:c4035716-4035399 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT260101 WP_012542525.1 NZ_CP106964:c4035406-4035119 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References