Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4095575..4096116 Replicon chromosome
Accession NZ_CP106929
Organism Escherichia coli strain MFDS1001074

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag OEG89_RS20350 Protein ID WP_000615983.1
Coordinates 4095575..4095853 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag OEG89_RS20355 Protein ID WP_000729703.1
Coordinates 4095856..4096116 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG89_RS20335 (4093157) 4093157..4093735 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
OEG89_RS20340 (4093941) 4093941..4094708 + 768 WP_000333380.1 class II glutamine amidotransferase -
OEG89_RS20345 (4094679) 4094679..4095419 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OEG89_RS20350 (4095575) 4095575..4095853 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OEG89_RS20355 (4095856) 4095856..4096116 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OEG89_RS20360 (4096326) 4096326..4097075 + 750 WP_000056849.1 C40 family peptidase -
OEG89_RS20365 (4097251) 4097251..4097748 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
OEG89_RS20370 (4097972) 4097972..4099684 - 1713 Protein_3964 flagellar biosynthesis protein FlhA -
OEG89_RS20375 (4099656) 4099656..4100441 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp1/tssD1 / tssA / rhs/PAAR / gmhA/lpcA 4072188..4131621 59433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T260084 WP_000615983.1 NZ_CP106929:c4095853-4095575 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT260084 WP_000729703.1 NZ_CP106929:c4096116-4095856 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References