Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2280186..2280985 Replicon chromosome
Accession NZ_CP106929
Organism Escherichia coli strain MFDS1001074

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag OEG89_RS11545 Protein ID WP_000347273.1
Coordinates 2280186..2280650 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OEG89_RS11550 Protein ID WP_001307405.1
Coordinates 2280650..2280985 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG89_RS11515 (2275187) 2275187..2275621 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
OEG89_RS11520 (2275639) 2275639..2276517 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
OEG89_RS11525 (2276507) 2276507..2277286 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
OEG89_RS11530 (2277297) 2277297..2277770 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
OEG89_RS11535 (2277793) 2277793..2279073 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
OEG89_RS11540 (2279322) 2279322..2280131 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OEG89_RS11545 (2280186) 2280186..2280650 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OEG89_RS11550 (2280650) 2280650..2280985 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OEG89_RS11555 (2281134) 2281134..2282705 - 1572 WP_001273753.1 galactarate dehydratase -
OEG89_RS11560 (2283080) 2283080..2284414 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
OEG89_RS11565 (2284430) 2284430..2285200 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2255315..2291860 36545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T260078 WP_000347273.1 NZ_CP106929:c2280650-2280186 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT260078 WP_001307405.1 NZ_CP106929:c2280985-2280650 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References