Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3813563..3814104 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag OEG87_RS18795 Protein ID WP_000615976.1
Coordinates 3813826..3814104 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag OEG87_RS18790 Protein ID WP_000729704.1
Coordinates 3813563..3813823 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS18765 (3809346) 3809346..3810131 - 786 WP_000207567.1 putative lateral flagellar export/assembly protein LafU -
OEG87_RS18770 (3810103) 3810103..3811815 + 1713 Protein_3672 flagellar biosynthesis protein FlhA -
OEG87_RS18775 (3811920) 3811920..3812198 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
OEG87_RS18780 (3812191) 3812191..3812547 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
OEG87_RS18785 (3812604) 3812604..3813377 - 774 WP_000543897.1 C40 family peptidase -
OEG87_RS18790 (3813563) 3813563..3813823 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OEG87_RS18795 (3813826) 3813826..3814104 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OEG87_RS18800 (3814260) 3814260..3815000 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OEG87_RS18805 (3814971) 3814971..3815738 - 768 WP_000333380.1 class II glutamine amidotransferase -
OEG87_RS18810 (3815944) 3815944..3816522 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T260060 WP_000615976.1 NZ_CP106924:3813826-3814104 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT260060 WP_000729704.1 NZ_CP106924:3813563-3813823 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References