Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 609763..610562 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag OEG87_RS02990 Protein ID WP_000347251.1
Coordinates 609763..610227 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag OEG87_RS02995 Protein ID WP_001308975.1
Coordinates 610227..610562 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS02960 (604764) 604764..605198 - 435 WP_087901835.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
OEG87_RS02965 (605216) 605216..606094 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
OEG87_RS02970 (606084) 606084..606863 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
OEG87_RS02975 (606874) 606874..607347 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
OEG87_RS02980 (607370) 607370..608650 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
OEG87_RS02985 (608899) 608899..609708 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
OEG87_RS02990 (609763) 609763..610227 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OEG87_RS02995 (610227) 610227..610562 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OEG87_RS03000 (610711) 610711..612282 - 1572 WP_075826719.1 galactarate dehydratase -
OEG87_RS03005 (612657) 612657..613991 + 1335 WP_075826720.1 galactarate/glucarate/glycerate transporter GarP -
OEG87_RS03010 (614007) 614007..614777 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T260044 WP_000347251.1 NZ_CP106924:c610227-609763 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT260044 WP_001308975.1 NZ_CP106924:c610562-610227 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References