Detailed information of TA system TA260033

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 97091..97517
• Replicon: plasmid unnamed3
• Accession: NZ_CP106915
• Organism: Klebsiella pneumoniae strain BSIKPN-9

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: OE131_RS29955
• Protein ID: WP_001372321.1
• Coordinates: 97392..97517 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	97091..97315 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OE131_RS29920 (92201)	92201..92656	-	456	Protein_129	hypothetical protein	-
OE131_RS29925 (92958)	92958..93485	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
OE131_RS29930 (93543)	93543..93776	+	234	WP_000006003.1	DUF905 family protein	-
OE131_RS29935 (93837)	93837..95860	+	2024	Protein_132	ParB/RepB/Spo0J family partition protein	-
OE131_RS29940 (95929)	95929..96363	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
OE131_RS29945 (96360)	96360..97079	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
- (97091)	97091..97315	+	225	NuclAT_0	-	Antitoxin
- (97091)	97091..97315	+	225	NuclAT_0	-	Antitoxin
- (97091)	97091..97315	+	225	NuclAT_0	-	Antitoxin
- (97091)	97091..97315	+	225	NuclAT_0	-	Antitoxin
OE131_RS29950 (97301)	97301..97450	+	150	Protein_135	plasmid maintenance protein Mok	-
OE131_RS29955 (97392)	97392..97517	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
OE131_RS29960 (97836)	97836..98132	-	297	Protein_137	hypothetical protein	-
OE131_RS29965 (98432)	98432..98728	+	297	WP_001272251.1	hypothetical protein	-
OE131_RS29970 (98839)	98839..99660	+	822	WP_001234445.1	DUF932 domain-containing protein	-
OE131_RS29975 (99957)	99957..100604	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
OE131_RS29980 (100881)	100881..101264	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
OE131_RS29985 (101455)	101455..102141	+	687	WP_015059009.1	PAS domain-containing protein	-
OE131_RS29990 (102235)	102235..102462	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaKPC-2 / fosA3 / blaTEM-1B / rmtB	-	1..120349	120349

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T260033 WP_001372321.1 NZ_CP106915:97392-97517 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT260033 NZ_CP106915:97091-97315 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin