Detailed information of TA system TA259998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 44928..45354
• Replicon: plasmid unnamed1
• Accession: NZ_CP106907
• Organism: Klebsiella pneumoniae strain BSIKPN-11

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: OE130_RS27380
• Protein ID: WP_001372321.1
• Coordinates: 44928..45053 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	45130..45354 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OE130_RS27345 (39983)	39983..40210	-	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-
OE130_RS27350 (40304)	40304..40990	-	687	WP_015059009.1	PAS domain-containing protein	-
OE130_RS27355 (41181)	41181..41564	-	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
OE130_RS27360 (41841)	41841..42488	+	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
OE130_RS27365 (42785)	42785..43606	-	822	WP_001234445.1	DUF932 domain-containing protein	-
OE130_RS27370 (43717)	43717..44013	-	297	WP_001272251.1	hypothetical protein	-
OE130_RS27375 (44313)	44313..44609	+	297	Protein_55	hypothetical protein	-
OE130_RS27380 (44928)	44928..45053	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
OE130_RS27385 (44995)	44995..45144	-	150	Protein_57	plasmid maintenance protein Mok	-
- (45130)	45130..45354	-	225	NuclAT_0	-	Antitoxin
- (45130)	45130..45354	-	225	NuclAT_0	-	Antitoxin
- (45130)	45130..45354	-	225	NuclAT_0	-	Antitoxin
- (45130)	45130..45354	-	225	NuclAT_0	-	Antitoxin
OE130_RS27390 (45366)	45366..46085	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
OE130_RS27395 (46082)	46082..46516	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
OE130_RS27400 (46585)	46585..48608	-	2024	Protein_60	ParB/RepB/Spo0J family partition protein	-
OE130_RS27405 (48669)	48669..48902	-	234	WP_000006003.1	DUF905 family protein	-
OE130_RS27410 (48960)	48960..49487	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
OE130_RS27415 (49789)	49789..50244	+	456	Protein_63	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	rmtB / blaTEM-1B / fosA3 / blaKPC-2	-	1..216864	216864

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T259998 WP_001372321.1 NZ_CP106907:c45053-44928 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT259998 NZ_CP106907:c45354-45130 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin