Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 772203..772978 Replicon chromosome
Accession NZ_CP106890
Organism Klebsiella pneumoniae strain KPN_SINK_001

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag N6138_RS03900 Protein ID WP_004150910.1
Coordinates 772493..772978 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag N6138_RS03895 Protein ID WP_004150912.1
Coordinates 772203..772496 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6138_RS03875 (N6138_03875) 767411..768013 - 603 WP_002916735.1 short chain dehydrogenase -
N6138_RS03880 (N6138_03880) 768111..769022 + 912 WP_004188550.1 LysR family transcriptional regulator -
N6138_RS03885 (N6138_03885) 769023..770171 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
N6138_RS03890 (N6138_03890) 770182..771558 - 1377 WP_004217775.1 cystathionine beta-synthase -
N6138_RS03895 (N6138_03895) 772203..772496 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
N6138_RS03900 (N6138_03900) 772493..772978 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
N6138_RS03905 (N6138_03905) 773682..774275 + 594 WP_004188553.1 hypothetical protein -
N6138_RS03910 (N6138_03910) 774372..774588 + 217 Protein_769 transposase -
N6138_RS03915 (N6138_03915) 775194..776066 + 873 WP_004188557.1 ParA family protein -
N6138_RS03920 (N6138_03920) 776066..776449 + 384 WP_004150906.1 hypothetical protein -
N6138_RS03925 (N6138_03925) 776442..777809 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 774372..774524 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T259954 WP_004150910.1 NZ_CP106890:772493-772978 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT259954 WP_004150912.1 NZ_CP106890:772203-772496 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References