Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 772193..772968 Replicon chromosome
Accession NZ_CP106886
Organism Klebsiella pneumoniae strain KPN_PAT_001

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag N6137_RS03900 Protein ID WP_004150910.1
Coordinates 772483..772968 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag N6137_RS03895 Protein ID WP_004150912.1
Coordinates 772193..772486 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6137_RS03875 (N6137_03875) 767401..768003 - 603 WP_002916735.1 short chain dehydrogenase -
N6137_RS03880 (N6137_03880) 768101..769012 + 912 WP_004188550.1 LysR family transcriptional regulator -
N6137_RS03885 (N6137_03885) 769013..770161 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
N6137_RS03890 (N6137_03890) 770172..771548 - 1377 WP_004217775.1 cystathionine beta-synthase -
N6137_RS03895 (N6137_03895) 772193..772486 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
N6137_RS03900 (N6137_03900) 772483..772968 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
N6137_RS03905 (N6137_03905) 773672..774265 + 594 WP_004188553.1 hypothetical protein -
N6137_RS03910 (N6137_03910) 774362..774578 + 217 Protein_769 transposase -
N6137_RS03915 (N6137_03915) 775184..776056 + 873 WP_004188557.1 ParA family protein -
N6137_RS03920 (N6137_03920) 776056..776439 + 384 WP_004150906.1 hypothetical protein -
N6137_RS03925 (N6137_03925) 776432..777799 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 774362..774514 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T259937 WP_004150910.1 NZ_CP106886:772483-772968 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT259937 WP_004150912.1 NZ_CP106886:772193-772486 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References