Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 16998..17682 Replicon plasmid unnamed2
Accession NZ_CP106883
Organism Acidovorax sp. 5MLIR

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M9799_RS20015 Protein ID WP_231045138.1
Coordinates 17317..17682 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9799_RS20010 Protein ID WP_231045137.1
Coordinates 16998..17324 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9799_RS19990 (M9799_19990) 12684..13172 + 489 WP_231045134.1 conjugal transfer protein TrbH -
M9799_RS19995 (M9799_19995) 13560..14501 + 942 WP_263726283.1 TrbI/VirB10 family protein -
M9799_RS20000 (M9799_20000) 14555..15541 - 987 Protein_19 DUF4238 domain-containing protein -
M9799_RS20005 (M9799_20005) 15711..16019 - 309 WP_231045136.1 H-NS histone family protein -
M9799_RS20010 (M9799_20010) 16998..17324 - 327 WP_231045137.1 XRE family transcriptional regulator Antitoxin
M9799_RS20015 (M9799_20015) 17317..17682 - 366 WP_231045138.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9799_RS20020 (M9799_20020) 17830..18273 + 444 WP_231045149.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
M9799_RS20025 (M9799_20025) 18276..18404 + 129 Protein_24 DNA polymerase V subunit UmuC -
M9799_RS20030 (M9799_20030) 18590..19789 - 1200 WP_231045139.1 MFS transporter -
M9799_RS20035 (M9799_20035) 19802..20494 - 693 WP_255662852.1 arsenical resistance protein ArsH -
M9799_RS20040 (M9799_20040) 20505..20936 - 432 WP_231045141.1 arsenate reductase (glutaredoxin) -
M9799_RS20045 (M9799_20045) 20962..22251 - 1290 WP_231045142.1 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..131045 131045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-87)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13931.43 Da        Isoelectric Point: 5.5367

>T259927 WP_231045138.1 NZ_CP106883:c17682-17317 [Acidovorax sp. 5MLIR]
MKWDVEYTDDFGDWWAGLTAEEQESLDTSVRLLEARGPTLGFPHSSGINGSRHSHMRELRTQHDGRPLRTLYAFDPRRSA
ILLIGGDKTGNDRWYDVHVPIADRLYDEHLEQLRKEGLING

Download         Length: 366 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12015.96 Da        Isoelectric Point: 10.2652

>AT259927 WP_231045137.1 NZ_CP106883:c17324-16998 [Acidovorax sp. 5MLIR]
MAKKFSELRQQMSPEAQARAEVQAQAMLAEMPLNELRQARGLSQKMLADVLRVQQPSIAKMERRTDMYLSTLRSHIEAMG
GQLEIVARFPDGAVKINNFADLSGKAVA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References