Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4269476..4270185 Replicon chromosome
Accession NZ_CP106873
Organism Mycobacterium avium subsp. paratuberculosis K-10

Toxin (Protein)


Gene name HigB2 Uniprot ID X7V9P5
Locus tag OBK31_RS20090 Protein ID WP_003873387.1
Coordinates 4269476..4269880 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID Q73S10
Locus tag OBK31_RS20095 Protein ID WP_003873388.1
Coordinates 4269877..4270185 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OBK31_RS20065 (OBK31_20065) 4264790..4265620 - 831 WP_003874399.1 hypothetical protein -
OBK31_RS20070 (OBK31_20070) 4266018..4266326 + 309 WP_003874400.1 WhiB family transcriptional regulator -
OBK31_RS20075 (OBK31_20075) 4266369..4267133 + 765 WP_003874401.1 superoxide dismutase family protein -
OBK31_RS20080 (OBK31_20080) 4267290..4268489 - 1200 WP_010950287.1 FAD-dependent oxidoreductase -
OBK31_RS20085 (OBK31_20085) 4268544..4269236 - 693 WP_010950286.1 DUF4352 domain-containing protein -
OBK31_RS20090 (OBK31_20090) 4269476..4269880 + 405 WP_003873387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OBK31_RS20095 (OBK31_20095) 4269877..4270185 + 309 WP_003873388.1 helix-turn-helix transcriptional regulator Antitoxin
OBK31_RS20100 (OBK31_20100) 4270672..4272198 - 1527 WP_003879517.1 adenylate/guanylate cyclase domain-containing protein -
OBK31_RS20105 (OBK31_20105) 4272293..4273909 - 1617 WP_003873390.1 chaperonin GroEL -
OBK31_RS20110 (OBK31_20110) 4273998..4274300 - 303 WP_003873391.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(31-91)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15503.82 Da        Isoelectric Point: 10.3815

>T259919 WP_003873387.1 NZ_CP106873:4269476-4269880 [Mycobacterium avium subsp. paratuberculosis K-10]
VRKWEVDLTLIEAWMDALDDEEYDNLIAALEQLEEHGPITRRPFVDTLEGSRHPNMKELRPRPTKAGAHIRVLFAFDTRS
RAIMLIAGDKAGNWSKWYAKHIPIADELFDAHQKRLHKAAAKATNRKPRKGKKR

Download         Length: 405 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11445.94 Da        Isoelectric Point: 10.0801

>AT259919 WP_003873388.1 NZ_CP106873:4269877-4270185 [Mycobacterium avium subsp. paratuberculosis K-10]
MTNLDDMRRRRPGNRTRIDAIKAEMDREVAQYRLRELREAAGYTQTTLAAAIGVGQNRVSQMEHGDLGTSRVDTLRKYVE
ATGGELEVSVKRPDGSRVLLSL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X7V9P5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4U5M0

References