259896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1963258..1963933 Replicon chromosome
Accession NZ_CP106849
Organism Edwardsiella ictaluri strain 669

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N8I66_RS09275 Protein ID WP_233420345.1
Coordinates 1963258..1963635 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag N8I66_RS09280 Protein ID WP_015871333.1
Coordinates 1963625..1963933 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I66_RS09240 (N8I66_09240) 1958282..1958629 - 348 WP_035608895.1 phage holin, lambda family -
N8I66_RS09245 (N8I66_09245) 1958713..1959042 - 330 WP_049640650.1 type II toxin-antitoxin system RelE/ParE family toxin -
N8I66_RS09250 (N8I66_09250) 1959017..1959247 - 231 WP_015871327.1 ParD-like family protein -
N8I66_RS09255 (N8I66_09255) 1959379..1959623 - 245 Protein_1780 transposase -
N8I66_RS09260 (N8I66_09260) 1959729..1960547 - 819 WP_198077051.1 hypothetical protein -
N8I66_RS09265 (N8I66_09265) 1960612..1961952 - 1341 WP_049640648.1 Fic family protein -
N8I66_RS09270 (N8I66_09270) 1962081..1962851 - 771 WP_198077052.1 Rha family transcriptional regulator -
N8I66_RS09275 (N8I66_09275) 1963258..1963635 + 378 WP_233420345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I66_RS09280 (N8I66_09280) 1963625..1963933 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
N8I66_RS09285 (N8I66_09285) 1964184..1964441 + 258 WP_198077053.1 DUF4160 domain-containing protein -
N8I66_RS09290 (N8I66_09290) 1964451..1964963 + 513 WP_015871334.1 DUF2442 domain-containing protein -
N8I66_RS09295 (N8I66_09295) 1965035..1965334 - 300 WP_049640646.1 XRE family transcriptional regulator -
N8I66_RS09300 (N8I66_09300) 1965336..1965686 - 351 WP_198077054.1 type II toxin-antitoxin system RelE/ParE family toxin -
N8I66_RS09305 (N8I66_09305) 1965736..1966047 - 312 WP_049640644.1 DUF1364 family protein -
N8I66_RS09310 (N8I66_09310) 1966050..1966694 - 645 WP_198077055.1 DUF1367 family protein -
N8I66_RS09315 (N8I66_09315) 1966804..1967151 - 348 WP_015871339.1 hypothetical protein -
N8I66_RS09320 (N8I66_09320) 1967181..1968563 - 1383 WP_049640642.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1928030..1985821 57791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14680.05 Da        Isoelectric Point: 10.1221

>T259896 WP_233420345.1 NZ_CP106849:1963258-1963635 [Edwardsiella ictaluri]
MGKNLRKHNNIVMFHSMNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGI
ARVFYCTLTGKRIVMLHSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 378 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT259896 WP_015871333.1 NZ_CP106849:1963625-1963933 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References