Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3940703..3941300 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag N9H76_RS19365 Protein ID WP_004893639.1
Coordinates 3940983..3941300 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag N9H76_RS19360 Protein ID WP_004142561.1
Coordinates 3940703..3940990 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS19330 (N9H76_19330) 3936783..3937031 + 249 WP_032410665.1 DUF1158 domain-containing protein -
N9H76_RS19335 (N9H76_19335) 3937049..3937390 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
N9H76_RS19340 (N9H76_19340) 3937421..3938536 - 1116 WP_075210499.1 MBL fold metallo-hydrolase -
N9H76_RS19345 (N9H76_19345) 3938716..3939297 + 582 WP_032410661.1 TetR/AcrR family transcriptional regulator -
N9H76_RS19350 (N9H76_19350) 3939297..3939665 + 369 WP_032421096.1 MmcQ/YjbR family DNA-binding protein -
N9H76_RS19355 (N9H76_19355) 3939785..3940438 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
N9H76_RS19360 (N9H76_19360) 3940703..3940990 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
N9H76_RS19365 (N9H76_19365) 3940983..3941300 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N9H76_RS19370 (N9H76_19370) 3941485..3942528 - 1044 WP_032410657.1 DUF2157 domain-containing protein -
N9H76_RS19375 (N9H76_19375) 3943194..3944060 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
N9H76_RS19380 (N9H76_19380) 3944169..3945596 + 1428 WP_114271149.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T259823 WP_004893639.1 NZ_CP106786:c3941300-3940983 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT259823 WP_004142561.1 NZ_CP106786:c3940990-3940703 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References