Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 356149..356795 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N9H76_RS01655 Protein ID WP_023317328.1
Coordinates 356149..356496 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N9H76_RS01660 Protein ID WP_032412314.1
Coordinates 356496..356795 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS01645 (N9H76_01645) 352075..353508 + 1434 WP_021312823.1 glycogen synthase GlgA -
N9H76_RS01650 (N9H76_01650) 353526..355973 + 2448 WP_002920561.1 glycogen phosphorylase -
N9H76_RS01655 (N9H76_01655) 356149..356496 + 348 WP_023317328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N9H76_RS01660 (N9H76_01660) 356496..356795 + 300 WP_032412314.1 XRE family transcriptional regulator Antitoxin
N9H76_RS01665 (N9H76_01665) 356858..358366 - 1509 WP_032412313.1 glycerol-3-phosphate dehydrogenase -
N9H76_RS01670 (N9H76_01670) 358571..358900 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
N9H76_RS01675 (N9H76_01675) 358951..359781 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
N9H76_RS01680 (N9H76_01680) 359831..360589 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13562.60 Da        Isoelectric Point: 6.2327

>T259813 WP_023317328.1 NZ_CP106786:356149-356496 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10828.64 Da        Isoelectric Point: 10.1464

>AT259813 WP_032412314.1 NZ_CP106786:356496-356795 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGIKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References