Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2543664..2543896 Replicon chromosome
Accession NZ_CP106757
Organism Enterococcus faecalis strain NY13410

Toxin (Protein)


Gene name txpA Uniprot ID Q837V5
Locus tag N8I78_RS12175 Protein ID WP_002366178.1
Coordinates 2543780..2543896 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2543664..2543869 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I78_RS12155 2539151..2540239 - 1089 WP_002355572.1 diacylglycerol kinase -
N8I78_RS12160 2540258..2541688 - 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
N8I78_RS12165 2541688..2543157 - 1470 WP_002361259.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
N8I78_RS12170 2543157..2543462 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- 2543664..2543869 + 206 - - Antitoxin
N8I78_RS12175 2543780..2543896 - 117 WP_002366178.1 putative holin-like toxin Toxin
N8I78_RS12180 2544044..2546074 - 2031 WP_002361258.1 NAD-dependent DNA ligase LigA -
N8I78_RS12185 2546200..2548458 - 2259 WP_002363179.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4108.01 Da        Isoelectric Point: 5.9482

>T259744 WP_002366178.1 NZ_CP106757:c2543896-2543780 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT259744 NZ_CP106757:2543664-2543869 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G1S9M0

Antitoxin

Download structure file

References