Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2987856..2988358 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N8153_RS14735 Protein ID WP_000767829.1
Coordinates 2987856..2988110 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag N8153_RS14740 Protein ID WP_263082258.1
Coordinates 2988107..2988358 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS14705 (2982871) 2982871..2983098 - 228 WP_000985278.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
N8153_RS14710 (2983112) 2983112..2984170 - 1059 WP_000492312.1 thiosulfate utilization transporter TsuA/YeeE -
N8153_RS14715 (2984349) 2984349..2985707 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N8153_RS14720 (2985697) 2985697..2985759 - 63 WP_010723108.1 membrane protein YoeI -
N8153_RS14725 (2985974) 2985974..2986903 - 930 WP_000803374.1 LysR substrate-binding domain-containing protein -
N8153_RS14730 (2986949) 2986949..2987773 - 825 WP_000754737.1 SDR family oxidoreductase -
N8153_RS14735 (2987856) 2987856..2988110 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N8153_RS14740 (2988107) 2988107..2988358 - 252 WP_263082258.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N8153_RS14745 (2988641) 2988641..2988691 + 51 WP_001364200.1 his operon leader peptide -
N8153_RS14750 (2988837) 2988837..2989736 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
N8153_RS14755 (2989742) 2989742..2991046 + 1305 WP_001300981.1 histidinol dehydrogenase -
N8153_RS14760 (2991043) 2991043..2992113 + 1071 WP_000108985.1 histidinol-phosphate transaminase -
N8153_RS14765 (2992113) 2992113..2993180 + 1068 WP_000080118.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T259722 WP_000767829.1 NZ_CP106756:c2988110-2987856 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9321.61 Da        Isoelectric Point: 4.8090

>AT259722 WP_263082258.1 NZ_CP106756:c2988358-2988107 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEEHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References