Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1965015..1965660 Replicon chromosome
Accession NZ_CP106754
Organism Kosakonia sp. ML.JS2a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7922_RS09400 Protein ID WP_263100280.1
Coordinates 1965015..1965332 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7922_RS09405 Protein ID WP_263100281.1
Coordinates 1965358..1965660 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7922_RS09380 (N7922_09380) 1960298..1961038 + 741 WP_263100276.1 adenosylcobinamide-GDP ribazoletransferase -
N7922_RS09385 (N7922_09385) 1961066..1962124 + 1059 WP_263100277.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
N7922_RS09390 (N7922_09390) 1962128..1962439 - 312 WP_263100278.1 helix-turn-helix domain-containing protein -
N7922_RS09395 (N7922_09395) 1962678..1964780 + 2103 WP_263100279.1 elongation factor G -
N7922_RS09400 (N7922_09400) 1965015..1965332 + 318 WP_263100280.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7922_RS09405 (N7922_09405) 1965358..1965660 + 303 WP_263100281.1 helix-turn-helix transcriptional regulator Antitoxin
N7922_RS09410 (N7922_09410) 1965745..1966698 + 954 WP_263100283.1 L,D-transpeptidase -
N7922_RS09415 (N7922_09415) 1966757..1967068 - 312 WP_263100284.1 hypothetical protein -
N7922_RS09420 (N7922_09420) 1967106..1967561 - 456 WP_263100285.1 hypothetical protein -
N7922_RS09425 (N7922_09425) 1968012..1969442 + 1431 WP_263100287.1 efflux transporter outer membrane subunit -
N7922_RS09430 (N7922_09430) 1969439..1969669 + 231 Protein_1849 GNAT family N-acetyltransferase -
N7922_RS09435 (N7922_09435) 1969802..1970572 - 771 WP_263100288.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(8-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12066.93 Da        Isoelectric Point: 10.6042

>T259698 WP_263100280.1 NZ_CP106754:1965015-1965332 [Kosakonia sp. ML.JS2a]
MTKTFDNWFSTLGERDRASVLAALMVLREKGPALPRPWADTVKGSRYSNMKELRVQSRGDPLRVFFAFDPQRVGILLCAG
SKAGHEKRFYDVMIPTADREFRHHL

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11272.15 Da        Isoelectric Point: 6.4719

>AT259698 WP_263100281.1 NZ_CP106754:1965358-1965660 [Kosakonia sp. ML.JS2a]
MSKTLEQLITEQKPEVVAAAQVLAQEMLLNIHLAELRERVQKTQIEMAQALGLKQPTVAVMEKQGRDIKLSTLKRYIEAT
GSKLRIDIELPDGSHYDFAL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References