Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1474563..1475164 Replicon chromosome
Accession NZ_CP106753
Organism Chitiniphilus sp. CD1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag N8I74_RS06745 Protein ID WP_263126101.1
Coordinates 1474886..1475164 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8I74_RS06740 Protein ID WP_263126100.1
Coordinates 1474563..1474874 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I74_RS06700 (N8I74_06700) 1469578..1470078 + 501 WP_263126090.1 type II toxin-antitoxin system HicB family antitoxin -
N8I74_RS06705 (N8I74_06705) 1470057..1470509 + 453 WP_263126091.1 hypothetical protein -
N8I74_RS06710 (N8I74_06710) 1470556..1470732 + 177 WP_263126092.1 hypothetical protein -
N8I74_RS06715 (N8I74_06715) 1470895..1472241 + 1347 WP_263126093.1 hypothetical protein -
N8I74_RS06720 (N8I74_06720) 1472281..1472553 + 273 WP_263126094.1 hypothetical protein -
N8I74_RS06725 (N8I74_06725) 1472550..1473359 + 810 WP_263126095.1 hypothetical protein -
N8I74_RS06730 (N8I74_06730) 1473401..1473922 + 522 WP_263126097.1 hypothetical protein -
N8I74_RS06735 (N8I74_06735) 1474089..1474490 + 402 WP_263126098.1 hypothetical protein -
N8I74_RS06740 (N8I74_06740) 1474563..1474874 - 312 WP_263126100.1 HigA family addiction module antitoxin Antitoxin
N8I74_RS06745 (N8I74_06745) 1474886..1475164 - 279 WP_263126101.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8I74_RS06750 (N8I74_06750) 1475219..1476262 - 1044 WP_263126102.1 phage late control D family protein -
N8I74_RS06755 (N8I74_06755) 1476259..1476684 - 426 WP_263126103.1 phage tail protein -
N8I74_RS06760 (N8I74_06760) 1476696..1479833 - 3138 WP_263126104.1 phage tail tape measure protein -
N8I74_RS06765 (N8I74_06765) 1479790..1479966 - 177 WP_263126105.1 hypothetical protein -
N8I74_RS06770 (N8I74_06770) 1480033..1480152 - 120 WP_263126106.1 GpE family phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1460004..1501968 41964


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-71)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10298.62 Da        Isoelectric Point: 8.1004

>T259693 WP_263126101.1 NZ_CP106753:c1475164-1474886 [Chitiniphilus sp. CD1]
MIRSFADQATADLFAGKRVARFANIASVATRKLQQLDSAATLNALRAPPGNRLEQLHGDRAGQHSIRINDQWRVCFVWTA
EGVEHVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11299.09 Da        Isoelectric Point: 8.5567

>AT259693 WP_263126100.1 NZ_CP106753:c1474874-1474563 [Chitiniphilus sp. CD1]
MAIAAPKNGMRPVHPGEVLREDYLKPLHISANALAKALHVPASRINDIVLGRRGITVDTALRLVRYFGGDVQSWINLQTA
YDIKVAEQTIAADIEREVQPMAA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References