Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5149996..5150591 Replicon chromosome
Accession NZ_CP106745
Organism Pseudomonas aeruginosa strain PALA17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA17_RS24160 Protein ID WP_071538299.1
Coordinates 5150313..5150591 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA17_RS24155 Protein ID WP_003123432.1
Coordinates 5149996..5150301 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA17_RS24120 (PALA17_04792) 5145136..5145984 + 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA17_RS24130 (PALA17_04794) 5146151..5147092 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA17_RS24135 (PALA17_04795) 5147209..5147823 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA17_RS24140 (PALA17_04796) 5147865..5148449 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA17_RS24145 (PALA17_04797) 5148490..5149590 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA17_RS24155 (PALA17_04799) 5149996..5150301 - 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
PALA17_RS24160 5150313..5150591 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA17_RS24165 5150644..5150772 - 129 Protein_4771 integrase -
PALA17_RS24170 (PALA17_04800) 5150920..5153148 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA17_RS24175 (PALA17_04801) 5153218..5153865 - 648 WP_003095021.1 carbonate dehydratase -
PALA17_RS24180 (PALA17_04802) 5153927..5155165 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T259687 WP_071538299.1 NZ_CP106745:c5150591-5150313 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT259687 WP_003123432.1 NZ_CP106745:c5150301-5149996 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References