259675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3753532..3754114 Replicon chromosome
Accession NZ_CP106744
Organism Pseudomonas aeruginosa strain PALA16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA16_RS17400 Protein ID WP_176601308.1
Coordinates 3753532..3753843 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA16_RS17405 Protein ID WP_176601309.1
Coordinates 3753836..3754114 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA16_RS17355 (PALA16_03442) 3748860..3749093 - 234 WP_003450286.1 hypothetical protein -
PALA16_RS17360 (PALA16_03443) 3749278..3749778 + 501 WP_003139775.1 hypothetical protein -
PALA16_RS17365 (PALA16_03444) 3749799..3750170 - 372 WP_003139776.1 5-carboxymethyl-2-hydroxymuconate isomerase -
PALA16_RS17370 (PALA16_03445) 3750453..3750788 - 336 WP_003119150.1 hypothetical protein -
PALA16_RS17375 (PALA16_03446) 3751225..3751488 - 264 WP_034027332.1 hypothetical protein -
PALA16_RS17380 (PALA16_03447) 3751524..3751790 - 267 WP_034027340.1 hypothetical protein -
PALA16_RS17385 (PALA16_03448) 3751859..3752239 - 381 WP_003116780.1 hypothetical protein -
PALA16_RS17390 (PALA16_03449) 3752236..3752865 - 630 WP_176601306.1 glycoside hydrolase family 19 protein -
PALA16_RS17395 3752924..3753316 - 393 WP_176601307.1 hypothetical protein -
PALA16_RS17400 3753532..3753843 + 312 WP_176601308.1 transcriptional regulator Toxin
PALA16_RS17405 3753836..3754114 + 279 WP_176601309.1 helix-turn-helix domain-containing protein Antitoxin
PALA16_RS17410 (PALA16_03450) 3754310..3756301 - 1992 WP_176601311.1 SGNH/GDSL hydrolase family protein -
PALA16_RS17415 (PALA16_03451) 3756362..3759091 - 2730 WP_269972823.1 host specificity factor TipJ family phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3751225..3812938 61713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(24-92)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11566.24 Da        Isoelectric Point: 9.4368

>T259675 WP_176601308.1 NZ_CP106744:3753532-3753843 [Pseudomonas aeruginosa]
MRTVIETEIFKRYADDIWSDPEREEFIAWIAANSLAGDVIPGSGGLRKVRWSRPGMGKRGGARVIYYNAEEAQAIWLLIA
YTKSKFDNLPASTLSKLKEAMNG

Download         Length: 312 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10188.76 Da        Isoelectric Point: 8.7264

>AT259675 WP_176601309.1 NZ_CP106744:3753836-3754114 [Pseudomonas aeruginosa]
MDKELETFEADLLASIDEMKKGKAARSTHVELSPIAEIRAKVGMAQSEFALLLGVSVRTLQEWEQGRRSPSGAAKTLIKV
ASKHPETLRELR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References