Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5332443..5333038 Replicon chromosome
Accession NZ_CP106743
Organism Pseudomonas aeruginosa strain PALA15

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA15_RS24595 Protein ID WP_003113526.1
Coordinates 5332760..5333038 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA15_RS24590 Protein ID WP_003099268.1
Coordinates 5332443..5332748 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA15_RS24555 (PALA15_04881) 5327582..5328430 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA15_RS24565 (PALA15_04883) 5328597..5329538 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA15_RS24570 (PALA15_04884) 5329655..5330269 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA15_RS24575 (PALA15_04885) 5330311..5330895 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA15_RS24580 (PALA15_04886) 5330936..5332036 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA15_RS24590 (PALA15_04888) 5332443..5332748 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA15_RS24595 5332760..5333038 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA15_RS24600 5333091..5333219 - 129 Protein_4858 integrase -
PALA15_RS24605 (PALA15_04889) 5333367..5335595 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA15_RS24610 (PALA15_04890) 5335665..5336312 - 648 WP_003095021.1 carbonate dehydratase -
PALA15_RS24615 (PALA15_04891) 5336374..5337612 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T259671 WP_003113526.1 NZ_CP106743:c5333038-5332760 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT259671 WP_003099268.1 NZ_CP106743:c5332748-5332443 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References