Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1593004..1593599 Replicon chromosome
Accession NZ_CP106742
Organism Pseudomonas aeruginosa strain PALA14

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA14_RS07375 Protein ID WP_003117425.1
Coordinates 1593004..1593282 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA14_RS07380 Protein ID WP_003099268.1
Coordinates 1593294..1593599 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA14_RS07355 (PALA14_01453) 1588430..1589668 + 1239 WP_003113524.1 dipeptidase -
PALA14_RS07360 (PALA14_01454) 1589730..1590377 + 648 WP_003095021.1 carbonate dehydratase -
PALA14_RS07365 (PALA14_01455) 1590447..1592675 - 2229 WP_003099265.1 TonB-dependent receptor -
PALA14_RS07370 1592823..1592951 + 129 Protein_1452 integrase -
PALA14_RS07375 1593004..1593282 + 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA14_RS07380 (PALA14_01456) 1593294..1593599 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA14_RS07390 (PALA14_01458) 1594006..1595106 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA14_RS07395 (PALA14_01459) 1595147..1595731 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA14_RS07400 (PALA14_01460) 1595774..1596388 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA14_RS07405 (PALA14_01461) 1596505..1597446 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA14_RS07415 (PALA14_01463) 1597613..1598461 - 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T259659 WP_003117425.1 NZ_CP106742:1593004-1593282 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT259659 WP_003099268.1 NZ_CP106742:1593294-1593599 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References