259653

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4399114..4400351 Replicon chromosome
Accession NZ_CP106735
Organism Reichenbachiella sp. Wsw4-B4

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag N7E81_RS17740 Protein ID WP_263050942.1
Coordinates 4399114..4399908 (-) Length 265 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag N7E81_RS17745 Protein ID WP_263050943.1
Coordinates 4400037..4400351 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E81_RS17710 (N7E81_17710) 4394546..4395961 + 1416 WP_263050936.1 CotH kinase family protein -
N7E81_RS17715 (N7E81_17715) 4396234..4396836 + 603 WP_263050937.1 RNA polymerase sigma factor -
N7E81_RS17720 (N7E81_17720) 4396839..4397117 + 279 WP_263050938.1 hypothetical protein -
N7E81_RS17725 (N7E81_17725) 4397117..4397602 + 486 WP_263050939.1 periplasmic heavy metal sensor -
N7E81_RS17730 (N7E81_17730) 4397648..4397959 + 312 WP_263050940.1 conotoxin -
N7E81_RS17735 (N7E81_17735) 4398337..4398588 + 252 WP_263050941.1 hypothetical protein -
N7E81_RS17740 (N7E81_17740) 4399114..4399908 - 795 WP_263050942.1 HipA domain-containing protein Toxin
N7E81_RS17745 (N7E81_17745) 4400037..4400351 - 315 WP_263050943.1 HipA N-terminal domain-containing protein Antitoxin
N7E81_RS17750 (N7E81_17750) 4400320..4400553 - 234 WP_263053101.1 helix-turn-helix transcriptional regulator -
N7E81_RS17755 (N7E81_17755) 4401569..4402222 - 654 WP_263050944.1 response regulator transcription factor -
N7E81_RS17760 (N7E81_17760) 4402215..4404260 - 2046 WP_263050945.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(7-230)

Antitoxin

HipA, N-terminal subdomain 1

(5-100)


Sequences

Toxin        


Download         Length: 265 a.a.        Molecular weight: 30215.76 Da        Isoelectric Point: 7.2207

>T259653 WP_263050942.1 NZ_CP106735:c4399908-4399114 [Reichenbachiella sp. Wsw4-B4]
MIKGKTTVTGVQPKLSLHIEKPDNEPEKLTIVGLWGQYILKPQSPMWEELPQIEDLTMHLAQLSRIRTAKHSLVRLDSGE
LAYITKRMDRNEGVKKHMEDMCQLLGRLTEDKYKSSHEQIAKEIKRSSINPGLDLVRFYELTLFSFLTGNADMHLKNFSL
LKNEQGHYELAPAYDLVSSALVVEGDDEELALTLCGKKKRLRKSDFFSAMTTSGIPNKAAENILNKYSKLHNIWIDFINQ
SFLSEEMMGNYSQLIESKHNQLFG

Download         Length: 795 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12071.86 Da        Isoelectric Point: 4.4279

>AT259653 WP_263050943.1 NZ_CP106735:c4400351-4400037 [Reichenbachiella sp. Wsw4-B4]
MRKAKVLYQDEWAGTLTEDEEGYHFQYEYEYFAKGRAPISLTLQLQQEPFHSNILFPFFDGLIPEGWILDIVEKNWKVSE
KDRMGVLLVACKDCIGAVSIEPLI

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References