Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 782937..783532 Replicon chromosome
Accession NZ_CP106682
Organism Pseudomonas aeruginosa strain PALA13

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA13_RS03610 Protein ID WP_003113526.1
Coordinates 782937..783215 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA13_RS03615 Protein ID WP_003113527.1
Coordinates 783227..783532 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA13_RS03590 (PALA13_00715) 778363..779601 + 1239 WP_003113524.1 dipeptidase -
PALA13_RS03595 (PALA13_00716) 779663..780310 + 648 WP_003095021.1 carbonate dehydratase -
PALA13_RS03600 (PALA13_00717) 780380..782608 - 2229 WP_003113525.1 TonB-dependent receptor -
PALA13_RS03605 782756..782884 + 129 Protein_713 integrase -
PALA13_RS03610 782937..783215 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA13_RS03615 (PALA13_00718) 783227..783532 + 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA13_RS03620 783869..784282 + 414 WP_049231965.1 hypothetical protein -
PALA13_RS03625 (PALA13_00719) 784506..785168 + 663 WP_023087830.1 restriction endonuclease -
PALA13_RS03630 (PALA13_00720) 785425..787191 + 1767 WP_023087829.1 anti-phage dCTP deaminase -
PALA13_RS03635 787723..788058 - 336 WP_031633682.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T259645 WP_003113526.1 NZ_CP106682:782937-783215 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT259645 WP_003113527.1 NZ_CP106682:783227-783532 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References