259643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6653648..6654243 Replicon chromosome
Accession NZ_CP106681
Organism Pseudomonas aeruginosa strain PALA12

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA12_RS30710 Protein ID WP_003117425.1
Coordinates 6653648..6653926 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA12_RS30715 Protein ID WP_003099268.1
Coordinates 6653938..6654243 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA12_RS30690 (PALA12_06082) 6649074..6650312 + 1239 WP_014603324.1 C69 family dipeptidase -
PALA12_RS30695 (PALA12_06083) 6650374..6651021 + 648 WP_003095021.1 carbonate dehydratase -
PALA12_RS30700 (PALA12_06084) 6651091..6653319 - 2229 WP_269974056.1 TonB-dependent receptor -
PALA12_RS30705 6653467..6653595 + 129 Protein_6062 integrase -
PALA12_RS30710 6653648..6653926 + 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA12_RS30715 (PALA12_06085) 6653938..6654243 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA12_RS30720 6654620..6655147 + 528 WP_071535723.1 ATP-binding protein -
PALA12_RS30725 (PALA12_06086) 6655159..6656697 - 1539 WP_023082696.1 GNAT family N-acetyltransferase -
PALA12_RS30730 (PALA12_06087) 6656672..6657508 - 837 WP_223656480.1 helix-turn-helix domain-containing protein -
PALA12_RS30735 (PALA12_06088) 6657640..6657906 - 267 WP_016852153.1 hypothetical protein -
PALA12_RS30740 (PALA12_06089) 6658016..6658288 + 273 WP_003115921.1 hypothetical protein -
PALA12_RS30745 (PALA12_06090) 6658500..6658790 + 291 WP_023083237.1 DUF5447 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T259643 WP_003117425.1 NZ_CP106681:6653648-6653926 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT259643 WP_003099268.1 NZ_CP106681:6653938-6654243 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References