259636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5304480..5305075 Replicon chromosome
Accession NZ_CP106680
Organism Pseudomonas aeruginosa strain PALA11

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA11_RS24715 Protein ID WP_003117425.1
Coordinates 5304797..5305075 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA11_RS24710 Protein ID WP_003113527.1
Coordinates 5304480..5304785 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA11_RS24675 5299899..5300189 - 291 WP_034030046.1 DUF5447 family protein -
PALA11_RS24680 (PALA11_04902) 5300365..5300637 - 273 WP_004352675.1 hypothetical protein -
PALA11_RS24685 (PALA11_04903) 5300747..5301013 + 267 WP_023088595.1 hypothetical protein -
PALA11_RS24690 5301069..5301404 + 336 WP_031635219.1 hypothetical protein -
PALA11_RS24695 5301405..5301548 + 144 Protein_4877 DNA-binding protein -
PALA11_RS24700 (PALA11_04904) 5301739..5303544 + 1806 WP_023113594.1 NACHT domain-containing protein -
PALA11_RS24705 5303746..5304153 - 408 WP_049875498.1 hypothetical protein -
PALA11_RS24710 (PALA11_04905) 5304480..5304785 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA11_RS24715 5304797..5305075 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA11_RS24720 (PALA11_04906) 5305404..5307632 + 2229 WP_031631436.1 TonB-dependent receptor -
PALA11_RS24725 (PALA11_04907) 5307702..5308349 - 648 WP_003095021.1 carbonate dehydratase -
PALA11_RS24730 (PALA11_04908) 5308411..5309649 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T259636 WP_003117425.1 NZ_CP106680:c5305075-5304797 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT259636 WP_003113527.1 NZ_CP106680:c5304785-5304480 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References