Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4668184..4668865 Replicon chromosome
Accession NZ_CP106680
Organism Pseudomonas aeruginosa strain PALA11

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag PALA11_RS21765 Protein ID WP_003111825.1
Coordinates 4668500..4668865 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag PALA11_RS21760 Protein ID WP_003159602.1
Coordinates 4668184..4668507 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA11_RS21725 (PALA11_04319) 4664143..4664826 - 684 WP_003116489.1 TetR/AcrR family transcriptional regulator -
PALA11_RS21730 (PALA11_04320) 4664914..4665792 + 879 WP_003163191.1 hypothetical protein -
PALA11_RS21740 4666395..4666622 + 228 WP_269971960.1 hypothetical protein -
PALA11_RS21745 4666637..4667562 - 926 Protein_4301 tyrosine-type recombinase/integrase -
PALA11_RS21750 (PALA11_04323) 4667562..4667954 - 393 Protein_4302 hypothetical protein -
PALA11_RS21755 4667949..4668068 + 120 Protein_4303 IS5/IS1182 family transposase -
PALA11_RS21760 (PALA11_04324) 4668184..4668507 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
PALA11_RS21765 4668500..4668865 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA11_RS21770 4669156..4669330 - 175 Protein_4306 hypothetical protein -
PALA11_RS21775 (PALA11_04325) 4669537..4669809 + 273 WP_014603216.1 hypothetical protein -
PALA11_RS21780 (PALA11_04326) 4669839..4670264 - 426 WP_003116492.1 VOC family protein -
PALA11_RS21785 (PALA11_04327) 4670365..4671249 + 885 WP_016263831.1 LysR substrate-binding domain-containing protein -
PALA11_RS21790 (PALA11_04328) 4671222..4672175 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
PALA11_RS21795 (PALA11_04329) 4672396..4672830 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T259635 WP_003111825.1 NZ_CP106680:c4668865-4668500 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT259635 WP_003159602.1 NZ_CP106680:c4668507-4668184 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References