Detailed information of TA system TA025962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4263074..4263676
• Accession: NC_016810
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: SL1344_RS20715
• Protein ID: WP_001159630.1
• Coordinates: 4263074..4263385 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SL1344_RS20720
• Protein ID: WP_000362050.1
• Coordinates: 4263386..4263676 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SL1344_RS20680 (SL1344_3972)	4258187..4258786	+	600	WP_000965695.1	glucose-1-phosphatase	-
SL1344_RS20685 (SL1344_3973)	4258780..4259652	+	873	WP_000921427.1	virulence factor BrkB family protein	-
SL1344_RS20690 (SL1344_3974)	4259649..4260086	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
SL1344_RS20695 (SL1344_3975)	4260131..4261072	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
SL1344_RS20700 (SL1344_3976)	4261087..4261533	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
SL1344_RS20705 (SL1344_3977)	4261530..4261841	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
SL1344_RS20710 (SL1344_3978)	4261927..4262856	-	930	WP_001127703.1	alpha/beta hydrolase	-
SL1344_RS20715 (SL1344_3979)	4263074..4263385	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
SL1344_RS20720 (SL1344_3980)	4263386..4263676	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
SL1344_RS20725 (SL1344_3981)	4263723..4264652	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
SL1344_RS20730 (SL1344_3982)	4264649..4265284	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
SL1344_RS20735 (SL1344_3983)	4265281..4266183	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T25962 WP_001159630.1 NC_016810:4263074-4263385 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T25962 NC_016810:4263074-4263385 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT25962 WP_000362050.1 NC_016810:4263386-4263676 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT25962 NC_016810:4263386-4263676 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64