Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 692424..693078 Replicon plasmid pML.8a3
Accession NZ_CP106661
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7977_RS22150 Protein ID WP_125311245.1
Coordinates 692746..693078 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7977_RS22145 Protein ID WP_125311239.1
Coordinates 692424..692720 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS22110 (N7977_22110) 687556..687687 + 132 WP_262258341.1 hypothetical protein -
N7977_RS22115 (N7977_22115) 687689..688621 - 933 WP_021508860.1 AraC family transcriptional regulator -
N7977_RS22120 (N7977_22120) 688782..689516 + 735 WP_058758975.1 SDR family oxidoreductase -
N7977_RS22125 (N7977_22125) 689594..690562 - 969 WP_262258342.1 magnesium/cobalt transporter CorA -
N7977_RS22130 (N7977_22130) 690659..690979 - 321 WP_021508856.1 AzlD domain-containing protein -
N7977_RS22135 (N7977_22135) 690969..691643 - 675 WP_058758973.1 AzlC family ABC transporter permease -
N7977_RS22140 (N7977_22140) 691746..692294 + 549 WP_125311237.1 XRE family transcriptional regulator -
N7977_RS22145 (N7977_22145) 692424..692720 - 297 WP_125311239.1 NadS family protein Antitoxin
N7977_RS22150 (N7977_22150) 692746..693078 - 333 WP_125311245.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7977_RS22155 (N7977_22155) 693273..693794 + 522 WP_031279967.1 GNAT family N-acetyltransferase -
N7977_RS22160 (N7977_22160) 693791..695191 - 1401 WP_262258619.1 ATP-binding cassette domain-containing protein -
N7977_RS22165 (N7977_22165) 695191..695967 - 777 WP_262258620.1 ABC transporter permease subunit -
N7977_RS22170 (N7977_22170) 695970..696905 - 936 WP_262258343.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..742161 742161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(36-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12611.43 Da        Isoelectric Point: 9.7110

>T259613 WP_125311245.1 NZ_CP106661:c693078-692746 [Pantoea dispersa]
IGNYLEFIETRVFSKARKSLLADDNEFQELQVFLLEHHESGATISQTGGCRKIRWSRAGMGKQGGTRIIYYNRLSSGRIY
LLLIYPKNAKDDLNETEKALLKAFTQQINL

Download         Length: 333 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11221.97 Da        Isoelectric Point: 6.4823

>AT259613 WP_125311239.1 NZ_CP106661:c692720-692424 [Pantoea dispersa]
MEKQLFNDLLESVQEMVAIEQGHESPDINRIHRHELPDVKLIRKNAGLKQAEFADAMGVSVDLIRSWEQHRRSPTGPALK
MLYLIQQQPLLINALQAL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References