Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 622407..623061 Replicon plasmid pML.8a3
Accession NZ_CP106661
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7977_RS21765 Protein ID WP_262258314.1
Coordinates 622407..622778 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NDM6
Locus tag N7977_RS21770 Protein ID WP_021508926.1
Coordinates 622762..623061 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS21745 (N7977_21745) 617675..619054 + 1380 WP_262258312.1 heavy metal sensor histidine kinase -
N7977_RS21750 (N7977_21750) 619092..619745 - 654 WP_058770319.1 oxygen-insensitive NAD(P)H nitroreductase -
N7977_RS21755 (N7977_21755) 619850..620851 - 1002 WP_021508931.1 zinc-binding alcohol dehydrogenase family protein -
N7977_RS21760 (N7977_21760) 620988..621905 + 918 WP_058759023.1 LysR family transcriptional regulator -
N7977_RS21765 (N7977_21765) 622407..622778 + 372 WP_262258314.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7977_RS21770 (N7977_21770) 622762..623061 + 300 WP_021508926.1 XRE family transcriptional regulator Antitoxin
N7977_RS21775 (N7977_21775) 623139..623606 - 468 WP_058759022.1 hypothetical protein -
N7977_RS21780 (N7977_21780) 623792..624721 - 930 WP_262258316.1 ABC transporter substrate-binding protein -
N7977_RS21785 (N7977_21785) 624731..625465 - 735 WP_262258318.1 ABC transporter permease -
N7977_RS21790 (N7977_21790) 625449..626165 - 717 WP_215788040.1 ABC transporter ATP-binding protein -
N7977_RS21795 (N7977_21795) 626162..627130 - 969 WP_262258320.1 HesA/MoeB/ThiF family protein -
N7977_RS21800 (N7977_21800) 627141..627899 - 759 WP_010615680.1 thiazole synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..742161 742161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(10-88)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14397.59 Da        Isoelectric Point: 10.1752

>T259612 WP_262258314.1 NZ_CP106661:622407-622778 [Pantoea dispersa]
VWQVEATDRFWKWLQAQDEALRLDVLAALKLLAQDGPHLGRPFVDTLMLSRVPNMKELRVQSKARPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLRIAETEYHYHLNAIGETHNENLG

Download         Length: 372 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11265.00 Da        Isoelectric Point: 6.7255

>AT259612 WP_021508926.1 NZ_CP106661:622762-623061 [Pantoea dispersa]
MKTLDEMLAALTPEQQHQVDERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NDM6

References