Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3538431..3539016 Replicon chromosome
Accession NZ_CP106660
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name higB Uniprot ID U3TYM8
Locus tag N7977_RS16675 Protein ID WP_010615566.1
Coordinates 3538717..3539016 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NKX1
Locus tag N7977_RS16670 Protein ID WP_010615565.1
Coordinates 3538431..3538730 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS16650 (N7977_16650) 3534432..3535733 + 1302 WP_058759604.1 anaerobic C4-dicarboxylate transporter -
N7977_RS16655 (N7977_16655) 3535820..3537517 + 1698 WP_262256482.1 protein-disulfide reductase DsbD -
N7977_RS16660 (N7977_16660) 3537584..3538162 + 579 WP_021507771.1 transcriptional regulator -
N7977_RS16670 (N7977_16670) 3538431..3538730 - 300 WP_010615565.1 helix-turn-helix transcriptional regulator Antitoxin
N7977_RS16675 (N7977_16675) 3538717..3539016 - 300 WP_010615566.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7977_RS16680 (N7977_16680) 3539488..3539736 + 249 Protein_3247 LysR family transcriptional regulator -
N7977_RS16685 (N7977_16685) 3539837..3541006 - 1170 WP_021507773.1 Gfo/Idh/MocA family oxidoreductase -
N7977_RS16690 (N7977_16690) 3541017..3541940 - 924 WP_262256483.1 sugar phosphate isomerase/epimerase -
N7977_RS16695 (N7977_16695) 3541939..3542109 + 171 WP_262256484.1 hypothetical protein -
N7977_RS16700 (N7977_16700) 3542139..3543158 - 1020 WP_262256485.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-87)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11308.01 Da        Isoelectric Point: 10.2176

>T259608 WP_010615566.1 NZ_CP106660:c3539016-3538717 [Pantoea dispersa]
MIEDVLASLAVLREFGPTLGRPDVDTLVGSRFSNMKELRVQSNGRAIRAFFAFDPVRRAIVLCAGNKTGTHQRRFYQAMI
KLADREYQQHLEEMNHAKT

Download         Length: 300 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10921.75 Da        Isoelectric Point: 9.7643

>AT259608 WP_010615565.1 NZ_CP106660:c3538730-3538431 [Pantoea dispersa]
MPKLEDLIAQRSPESQARIRNKAAEKILEIRLRQLREELALSQVQLAEKMGVSQPAIAAIEARGDELKLSSLKKYVEALG
GKLSVTVELPAGDGRIFQL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NKX1

References