Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3147043..3147767 Replicon chromosome
Accession NZ_CP106660
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7977_RS14900 Protein ID WP_031279671.1
Coordinates 3147043..3147354 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7977_RS14905 Protein ID WP_021313564.1
Coordinates 3147351..3147767 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS14885 (N7977_14885) 3142368..3144818 + 2451 WP_159377485.1 acyl-CoA dehydrogenase FadE -
N7977_RS14890 (N7977_14890) 3145003..3146163 + 1161 WP_031279670.1 pyridoxal phosphate-dependent aminotransferase -
N7977_RS14895 (N7977_14895) 3146151..3146921 + 771 WP_262256382.1 amidohydrolase -
N7977_RS14900 (N7977_14900) 3147043..3147354 + 312 WP_031279671.1 type II toxin-antitoxin system HigB family toxin Toxin
N7977_RS14905 (N7977_14905) 3147351..3147767 + 417 WP_021313564.1 transcriptional regulator Antitoxin
N7977_RS14910 (N7977_14910) 3147809..3150007 - 2199 WP_262256383.1 catalase/peroxidase HPI -
N7977_RS14915 (N7977_14915) 3150302..3150637 - 336 WP_021507290.1 hydroxyisourate hydrolase -
N7977_RS14920 (N7977_14920) 3150634..3151128 - 495 WP_222951245.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N7977_RS14925 (N7977_14925) 3151141..3152400 - 1260 WP_262256384.1 allantoate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12241.10 Da        Isoelectric Point: 10.1870

>T259607 WP_031279671.1 NZ_CP106660:3147043-3147354 [Pantoea dispersa]
MHIISRKVFNEATQRFPNDAAALDATYRLLSGHDFADPQALKAWFPSLDRMKYREKWWVINVGGNNLRLMFFADFVAKRV
FVKHIVTHAEYDKLVKHYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15331.57 Da        Isoelectric Point: 7.4011

>AT259607 WP_021313564.1 NZ_CP106660:3147351-3147767 [Pantoea dispersa]
MISEAIQASNNLIKAVPLLGGSQSRADYEQALELVEYLVEHQPGHPLIEMLAVKVAKYEETAAEFAAFNARTQALPGGVA
LLRVLMDQHGLNQSSFVAEIGQRSYVNRILKGERRLTDKHKAALARRFNLPFEAFREA

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References