Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 167205..167885 Replicon chromosome
Accession NZ_CP106660
Organism Pantoea dispersa strain ML.8a3

Toxin (Protein)


Gene name higB Uniprot ID A0A246NHY2
Locus tag N7977_RS00760 Protein ID WP_059013049.1
Coordinates 167205..167504 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NHX0
Locus tag N7977_RS00765 Protein ID WP_058775157.1
Coordinates 167553..167885 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7977_RS00745 (N7977_00745) 163530..164024 + 495 WP_021507883.1 GNAT family N-acetyltransferase -
N7977_RS00750 (N7977_00750) 164401..165315 - 915 WP_021507882.1 sugar ABC transporter substrate-binding protein -
N7977_RS00755 (N7977_00755) 165751..167145 + 1395 WP_058775155.1 MFS transporter -
N7977_RS00760 (N7977_00760) 167205..167504 + 300 WP_059013049.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7977_RS00765 (N7977_00765) 167553..167885 + 333 WP_058775157.1 HigA family addiction module antitoxin Antitoxin
N7977_RS00770 (N7977_00770) 167977..169140 + 1164 WP_021507880.1 HD-GYP domain-containing protein -
N7977_RS00775 (N7977_00775) 169249..169338 + 90 WP_021507879.1 K(+)-transporting ATPase subunit F -
N7977_RS00780 (N7977_00780) 169338..171017 + 1680 WP_262256828.1 potassium-transporting ATPase subunit KdpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11503.22 Da        Isoelectric Point: 10.4912

>T259604 WP_059013049.1 NZ_CP106660:167205-167504 [Pantoea dispersa]
MGSIRAFRQAWLAQFYTHGTPHAQIPRAIESALARKLDIIHAATSHQDLRSPPGNRFEALKPPLLGYYSIRVNAQYRLIF
QWAKGEAWDLYLDPHRYKK

Download         Length: 300 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12751.58 Da        Isoelectric Point: 7.2039

>AT259604 WP_058775157.1 NZ_CP106660:167553-167885 [Pantoea dispersa]
MKQAMRKPTSVGDVLQYEFLEPLNLKVNDLAEMLNVHRNTVSALVNNNRKLSTEMAYRLARVFATSIEFWLNLQRHLDQW
EVENDARTQEELSRVMTLSAFLAQRGTQVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NHY2

Antitoxin

Source ID Structure
AlphaFold DB A0A246NHX0

References