25958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/-
Location 3701215..3701753 Replicon
Accession NC_016810
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag SL1344_RS18140 Protein ID WP_001526148.1
Coordinates 3701215..3701490 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag SL1344_RS18145 Protein ID WP_000729713.1
Coordinates 3701493..3701753 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SL1344_RS18135 (SL1344_3482) 3698422..3701127 + 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -
SL1344_RS18140 (SL1344_3483) 3701215..3701490 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
SL1344_RS18145 (SL1344_3484) 3701493..3701753 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SL1344_RS18150 (SL1344_3485) 3701862..3702881 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
SL1344_RS18155 (SL1344_3486) 3702885..3704099 - 1215 WP_001105521.1 RNA-splicing ligase RtcB -
SL1344_RS18160 (SL1344_3487) 3704447..3706000 - 1554 WP_000013008.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T25958 WP_001526148.1 NC_016810:c3701490-3701215 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T25958 NC_016810:c3701490-3701215 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT25958 WP_000729713.1 NC_016810:c3701753-3701493 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT25958 NC_016810:c3701753-3701493 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References