Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3837308..3837905 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag N7990_RS19080 Protein ID WP_004893639.1
Coordinates 3837588..3837905 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag N7990_RS19075 Protein ID WP_004142561.1
Coordinates 3837308..3837595 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS19045 (3833515) 3833515..3833763 + 249 WP_002893037.1 DUF1158 domain-containing protein -
N7990_RS19050 (3833781) 3833781..3834122 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
N7990_RS19055 (3834153) 3834153..3835268 - 1116 WP_074180844.1 MBL fold metallo-hydrolase -
N7990_RS19060 (3835448) 3835448..3836029 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
N7990_RS19065 (3836029) 3836029..3836397 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
N7990_RS19070 (3836517) 3836517..3837170 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
N7990_RS19075 (3837308) 3837308..3837595 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
N7990_RS19080 (3837588) 3837588..3837905 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7990_RS19085 (3838090) 3838090..3839133 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
N7990_RS19090 (3839803) 3839803..3840669 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
N7990_RS19095 (3840778) 3840778..3842205 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T259578 WP_004893639.1 NZ_CP106654:c3837905-3837588 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT259578 WP_004142561.1 NZ_CP106654:c3837595-3837308 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References