Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 730475..731250 Replicon chromosome
Accession NZ_CP106654
Organism Klebsiella pneumoniae strain KP5076

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag N7990_RS03615 Protein ID WP_004150910.1
Coordinates 730765..731250 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag N7990_RS03610 Protein ID WP_004150912.1
Coordinates 730475..730768 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7990_RS03590 (725683) 725683..726285 - 603 WP_002916735.1 short chain dehydrogenase -
N7990_RS03595 (726383) 726383..727294 + 912 WP_004188550.1 LysR family transcriptional regulator -
N7990_RS03600 (727295) 727295..728443 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
N7990_RS03605 (728454) 728454..729830 - 1377 WP_004217775.1 cystathionine beta-synthase -
N7990_RS03610 (730475) 730475..730768 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
N7990_RS03615 (730765) 730765..731250 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
N7990_RS03620 (731954) 731954..732546 + 593 Protein_711 hypothetical protein -
N7990_RS03625 (732643) 732643..732859 + 217 Protein_712 transposase -
N7990_RS03635 (733374) 733374..734087 - 714 WP_023328352.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 732643..732795 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T259572 WP_004150910.1 NZ_CP106654:730765-731250 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT259572 WP_004150912.1 NZ_CP106654:730475-730768 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References