Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3493626..3494353 Replicon chromosome
Accession NZ_CP104976
Organism Enterobacter sp. 155105

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N8O08_RS16845 Protein ID WP_223562699.1
Coordinates 3493626..3493937 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8O08_RS16850 Protein ID WP_223562698.1
Coordinates 3493934..3494353 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8O08_RS16820 (N8O08_16820) 3489411..3490190 - 780 WP_223562702.1 acetolactate decarboxylase -
N8O08_RS16825 (N8O08_16825) 3490296..3491192 + 897 WP_223562701.1 LysR family transcriptional regulator -
N8O08_RS16830 (N8O08_16830) 3491420..3491632 - 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
N8O08_RS16835 (N8O08_16835) 3492206..3492661 + 456 WP_223562700.1 hypothetical protein -
N8O08_RS16840 (N8O08_16840) 3492831..3493088 - 258 WP_137467519.1 hypothetical protein -
N8O08_RS16845 (N8O08_16845) 3493626..3493937 + 312 WP_223562699.1 type II toxin-antitoxin system HigB family toxin Toxin
N8O08_RS16850 (N8O08_16850) 3493934..3494353 + 420 WP_223562698.1 helix-turn-helix domain-containing protein Antitoxin
N8O08_RS16855 (N8O08_16855) 3494406..3495296 - 891 WP_223562697.1 oxidoreductase -
N8O08_RS16860 (N8O08_16860) 3495402..3496523 + 1122 WP_045401965.1 YbdK family carboxylate-amine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12354.28 Da        Isoelectric Point: 10.2553

>T259552 WP_223562699.1 NZ_CP104976:3493626-3493937 [Enterobacter sp. 155105]
MHVVSRAPFDTATRQFPNQALALGDLYRVLKKEHYPSPDDMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFLADFERGKI
FIKHISTHAEYDKLTELYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15496.44 Da        Isoelectric Point: 4.4285

>AT259552 WP_223562698.1 NZ_CP104976:3493934-3494353 [Enterobacter sp. 155105]
MNYAAAIKAANDLTNELPFLGSSPSRQDYEDALALVEYLVEHEPDSSLVEMLTAKIDKYENESPEFAEFNSRVASIPSGV
ALLRTLIDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFDLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References