Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 993190..993847 Replicon chromosome
Accession NZ_CP104976
Organism Enterobacter sp. 155105

Toxin (Protein)


Gene name higB Uniprot ID A0A1Z3MZ87
Locus tag N8O08_RS04785 Protein ID WP_063408809.1
Coordinates 993548..993847 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8O08_RS04780 Protein ID WP_214577165.1
Coordinates 993190..993537 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8O08_RS04750 (N8O08_04750) 988604..989206 - 603 WP_223561330.1 short chain dehydrogenase -
N8O08_RS04755 (N8O08_04755) 989304..990191 + 888 WP_223561329.1 LysR family transcriptional regulator -
N8O08_RS04760 (N8O08_04760) 990212..991393 + 1182 WP_223561328.1 PLP-dependent aminotransferase family protein -
N8O08_RS04765 (N8O08_04765) 991500..991919 - 420 WP_223561327.1 nuclear transport factor 2 family protein -
N8O08_RS04770 (N8O08_04770) 992017..992748 + 732 WP_223561326.1 helix-turn-helix transcriptional regulator -
N8O08_RS04775 (N8O08_04775) 992720..993145 - 426 WP_223561325.1 nucleoside triphosphatase NudI -
N8O08_RS04780 (N8O08_04780) 993190..993537 - 348 WP_214577165.1 HigA family addiction module antitoxin Antitoxin
N8O08_RS04785 (N8O08_04785) 993548..993847 - 300 WP_063408809.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8O08_RS04790 (N8O08_04790) 994098..995267 - 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
N8O08_RS04795 (N8O08_04795) 995278..997476 - 2199 WP_223561324.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11707.32 Da        Isoelectric Point: 10.0346

>T259547 WP_063408809.1 NZ_CP104976:c993847-993548 [Enterobacter sp. 155105]
MISYFRDQWLEDFFLYGRSSNVIPSNLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13055.98 Da        Isoelectric Point: 7.0134

>AT259547 WP_214577165.1 NZ_CP104976:c993537-993190 [Enterobacter sp. 155105]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3MZ87

Antitoxin

Source ID Structure

References