Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3704076..3704657 Replicon chromosome
Accession NZ_CP104973
Organism Phyllobacterium zundukense strain A18/3m

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N8E88_RS30605 Protein ID WP_262293809.1
Coordinates 3704076..3704360 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8E88_RS30610 Protein ID WP_262293810.1
Coordinates 3704373..3704657 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E88_RS30590 (N8E88_30600) 3700214..3700750 - 537 WP_262293806.1 hypothetical protein -
N8E88_RS30595 (N8E88_30605) 3700983..3701615 - 633 WP_262293807.1 LysE family translocator -
N8E88_RS30600 (N8E88_30610) 3701883..3704030 + 2148 WP_262293808.1 penicillin-binding protein 1A -
N8E88_RS30605 (N8E88_30615) 3704076..3704360 + 285 WP_262293809.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8E88_RS30610 (N8E88_30620) 3704373..3704657 + 285 WP_262293810.1 HigA family addiction module antitoxin Antitoxin
N8E88_RS30615 (N8E88_30625) 3704763..3705347 + 585 WP_262293811.1 DUF1214 domain-containing protein -
N8E88_RS30620 (N8E88_30630) 3705340..3705885 + 546 WP_262293812.1 hypothetical protein -
N8E88_RS30625 (N8E88_30635) 3705923..3706114 - 192 WP_262293813.1 hypothetical protein -
N8E88_RS30630 (N8E88_30640) 3706445..3707404 + 960 WP_262293814.1 DUF2336 domain-containing protein -
N8E88_RS30635 (N8E88_30645) 3707580..3707927 - 348 WP_262293815.1 DUF1491 family protein -
N8E88_RS30640 (N8E88_30650) 3708069..3708941 - 873 WP_262293816.1 peptidoglycan-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-62)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10914.50 Da        Isoelectric Point: 8.0019

>T259545 WP_262293809.1 NZ_CP104973:3704076-3704360 [Phyllobacterium zundukense]
MILTYRDKRTEAFARGEFVREFQGFERQAYKRLEILEAATSLAELRMLPSNRLEALKGDKSGQFSIRINMQWRICFEWPA
SAAGPSDVAIIDYH

Download         Length: 285 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10463.01 Da        Isoelectric Point: 7.3195

>AT259545 WP_262293810.1 NZ_CP104973:3704373-3704657 [Phyllobacterium zundukense]
MPRPAIHPGEILADELGELNIKPTELSRQINVPPNRITQIIHGKRAITGDTAVRLGHWFGTSAQFWLNLQSAYDIRLAEE
KSGAEIALLPTRLQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References