Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 470412..471044 Replicon plasmid p_unnamed1
Accession NZ_CP104964
Organism Devosia neptuniae strain A18/4-1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag N8A98_RS02235 Protein ID WP_262165429.1
Coordinates 470763..471044 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8A98_RS02230 Protein ID WP_262165428.1
Coordinates 470412..470723 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A98_RS02220 (N8A98_02220) 468675..469151 + 477 WP_262165424.1 conjugative transfer signal peptidase TraF -
N8A98_RS02225 (N8A98_02225) 469141..470307 + 1167 WP_262165426.1 conjugal transfer protein TraB -
N8A98_RS02230 (N8A98_02230) 470412..470723 - 312 WP_262165428.1 HigA family addiction module antitoxin Antitoxin
N8A98_RS02235 (N8A98_02235) 470763..471044 - 282 WP_262165429.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8A98_RS02240 (N8A98_02240) 471423..472301 - 879 WP_262165431.1 LysR family transcriptional regulator -
N8A98_RS02245 (N8A98_02245) 472637..473392 - 756 WP_262165432.1 SDR family oxidoreductase -
N8A98_RS02250 (N8A98_02250) 473533..474426 + 894 WP_262165434.1 AraC family transcriptional regulator -
N8A98_RS02255 (N8A98_02255) 474547..475608 - 1062 WP_262165435.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..532786 532786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10352.95 Da        Isoelectric Point: 10.4759

>T259521 WP_262165429.1 NZ_CP104964:c471044-470763 [Devosia neptuniae]
MAKSFKGIQLQIVASGKAPKGFPTDVLQAARRKLFMITNAAALQDLLMPPGNKLEALKGNRSGQHSIRINDQWRVCFRWS
NGAAEDIEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11466.20 Da        Isoelectric Point: 5.6939

>AT259521 WP_262165428.1 NZ_CP104964:c470723-470412 [Devosia neptuniae]
MSLTFDPPIHPGEILREEFLVPLNLSAGALAKRVSVPRTRIERIVKEETPITPDTALRLSRVLGTTAQFWMNMQSAYDLV
RAEQAHSEDLNLIAPLDSLARAS

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References