Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 470412..471044 Replicon plasmid p_unnamed1
Accession NZ_CP104964
Organism Devosia neptuniae strain A18/4-1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag N8A98_RS02235 Protein ID WP_262165429.1
Coordinates 470763..471044 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8A98_RS02230 Protein ID WP_262165428.1
Coordinates 470412..470723 (-) Length 104 a.a.

Genomic Context

N8A98_RS02220N8A98_RS02225N8A98_RS02250N8A98_RS02230N8A98_RS02235N8A98_RS02240N8A98_RS02245N8A98_RS02255
Location: 468675..469151 (477 bp)
Type: Others
Protein ID: WP_262165424.1
Location: 469141..470307 (1167 bp)
Type: Others
Protein ID: WP_262165426.1
Location: 473533..474426 (894 bp)
Type: Others
Protein ID: WP_262165434.1
Location: 470412..470723 (312 bp)
Type: Antitoxin
Protein ID: WP_262165428.1
Location: 470763..471044 (282 bp)
Type: Toxin
Protein ID: WP_262165429.1
Location: 471423..472301 (879 bp)
Type: Others
Protein ID: WP_262165431.1
Location: 472637..473392 (756 bp)
Type: Others
Protein ID: WP_262165432.1
Location: 474547..475608 (1062 bp)
Type: Others
Protein ID: WP_262165435.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N8A98_RS02220 (N8A98_02220)468675..469151+477WP_262165424.1conjugative transfer signal peptidase TraF-
N8A98_RS02225 (N8A98_02225)469141..470307+1167WP_262165426.1conjugal transfer protein TraB-
N8A98_RS02230 (N8A98_02230)470412..470723-312WP_262165428.1HigA family addiction module antitoxinAntitoxin
N8A98_RS02235 (N8A98_02235)470763..471044-282WP_262165429.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N8A98_RS02240 (N8A98_02240)471423..472301-879WP_262165431.1LysR family transcriptional regulator-
N8A98_RS02245 (N8A98_02245)472637..473392-756WP_262165432.1SDR family oxidoreductase-
N8A98_RS02250 (N8A98_02250)473533..474426+894WP_262165434.1AraC family transcriptional regulator-
N8A98_RS02255 (N8A98_02255)474547..475608-1062WP_262165435.1iron ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..532786532786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10352.95 Da        Isoelectric Point: 10.4759

>T259521 WP_262165429.1 NZ_CP104964:c471044-470763 [Devosia neptuniae]
MAKSFKGIQLQIVASGKAPKGFPTDVLQAARRKLFMITNAAALQDLLMPPGNKLEALKGNRSGQHSIRINDQWRVCFRWS
NGAAEDIEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11466.20 Da        Isoelectric Point: 5.6939

>AT259521 WP_262165428.1 NZ_CP104964:c470723-470412 [Devosia neptuniae]
MSLTFDPPIHPGEILREEFLVPLNLSAGALAKRVSVPRTRIERIVKEETPITPDTALRLSRVLGTTAQFWMNMQSAYDLV
RAEQAHSEDLNLIAPLDSLARAS

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References