Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2053024..2053684 Replicon chromosome
Accession NZ_CP104925
Organism Klebsiella pasteurii strain AHM8C130-1I

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5863_RS09605 Protein ID WP_087829044.1
Coordinates 2053024..2053377 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5863_RS09610 Protein ID WP_087829043.1
Coordinates 2053382..2053684 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5863_RS09580 (N5863_09580) 2048407..2049174 - 768 WP_004122251.1 molybdopterin-dependent oxidoreductase -
N5863_RS09585 (N5863_09585) 2049164..2049772 - 609 WP_112166277.1 cytochrome b/b6 domain-containing protein -
N5863_RS09590 (N5863_09590) 2049787..2050413 - 627 WP_112166276.1 hypothetical protein -
N5863_RS09595 (N5863_09595) 2050553..2051224 + 672 WP_004122240.1 heavy metal response regulator transcription factor -
N5863_RS09600 (N5863_09600) 2051221..2052639 + 1419 WP_004122238.1 heavy metal sensor histidine kinase -
N5863_RS09605 (N5863_09605) 2053024..2053377 + 354 WP_087829044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5863_RS09610 (N5863_09610) 2053382..2053684 + 303 WP_087829043.1 XRE family transcriptional regulator Antitoxin
N5863_RS09620 (N5863_09620) 2054087..2055544 + 1458 WP_123829136.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
N5863_RS09630 (N5863_09630) 2056568..2058022 - 1455 WP_004122234.1 AMP nucleosidase -
N5863_RS09635 (N5863_09635) 2058171..2058410 - 240 WP_284658974.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13535.43 Da        Isoelectric Point: 9.4800

>T259508 WP_087829044.1 NZ_CP104925:2053024-2053377 [Klebsiella pasteurii]
VWMIKTTDTFERWFTSLNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVSNEKRFYDEILPVADREYTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11026.78 Da        Isoelectric Point: 5.1992

>AT259508 WP_087829043.1 NZ_CP104925:2053382-2053684 [Klebsiella pasteurii]
MGRTLEQLIADEKPEVVAEAEAMAKDILLNIHLAELRERVQKTQVEMAQELGIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLSLNVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References