Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1127433..1128017 Replicon chromosome
Accession NZ_CP104917
Organism Avibacterium paragallinarum strain AP-2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag N8E87_RS05675 Protein ID WP_264246545.1
Coordinates 1127739..1128017 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8E87_RS05670 Protein ID WP_110478985.1
Coordinates 1127433..1127729 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E87_RS05655 (N8E87_05655) 1123346..1123825 + 480 WP_017806582.1 leucine-responsive transcriptional regulator Lrp -
N8E87_RS05660 (N8E87_05660) 1123827..1126679 + 2853 WP_264246541.1 DNA translocase FtsK 4TM domain-containing protein -
N8E87_RS05665 (N8E87_05665) 1126761..1127381 + 621 WP_264246543.1 outer membrane lipoprotein chaperone LolA -
N8E87_RS05670 (N8E87_05670) 1127433..1127729 - 297 WP_110478985.1 HigA family addiction module antitoxin Antitoxin
N8E87_RS05675 (N8E87_05675) 1127739..1128017 - 279 WP_264246545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8E87_RS05680 (N8E87_05680) 1128170..1129519 + 1350 WP_264246547.1 replication-associated recombination protein A -
N8E87_RS05685 (N8E87_05685) 1129593..1130882 + 1290 WP_115249899.1 serine--tRNA ligase -
N8E87_RS05690 (N8E87_05690) 1131086..1132162 + 1077 WP_264246549.1 peptide chain release factor 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10851.51 Da        Isoelectric Point: 9.2249

>T259490 WP_264246545.1 NZ_CP104917:c1128017-1127739 [Avibacterium paragallinarum]
MITHFTCKDTQAFFEGQRIRRFIPFEKVAMRKLQQLNAATELNFLRIPPGNHLEMLTGDRKGQYSIRINDQWRICFTWLN
GHAADVAIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11127.72 Da        Isoelectric Point: 7.3167

>AT259490 WP_110478985.1 NZ_CP104917:c1127729-1127433 [Avibacterium paragallinarum]
MTRQIPLSHPGEILLEEWLKPLGISQYALAKAISVPPRRINEIVKGKRAITPDTALRLATYFGTDPQSWLNLQSHYDTEQ
TRTAINEDLTHISPFQFA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References