Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1383251..1383835 Replicon chromosome
Accession NZ_CP104914
Organism Avibacterium paragallinarum strain AG21-0333

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag N8E86_RS06480 Protein ID WP_264255269.1
Coordinates 1383251..1383529 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8E86_RS06485 Protein ID WP_110478985.1
Coordinates 1383539..1383835 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E86_RS06465 (N8E86_06465) 1379100..1380182 - 1083 WP_264255264.1 peptide chain release factor 1 -
N8E86_RS06470 (N8E86_06470) 1380386..1381675 - 1290 WP_264255265.1 serine--tRNA ligase -
N8E86_RS06475 (N8E86_06475) 1381749..1383098 - 1350 WP_264255267.1 replication-associated recombination protein A -
N8E86_RS06480 (N8E86_06480) 1383251..1383529 + 279 WP_264255269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8E86_RS06485 (N8E86_06485) 1383539..1383835 + 297 WP_110478985.1 HigA family addiction module antitoxin Antitoxin
N8E86_RS06490 (N8E86_06490) 1383887..1384507 - 621 WP_264255271.1 outer membrane lipoprotein chaperone LolA -
N8E86_RS06495 (N8E86_06495) 1384589..1387441 - 2853 WP_264255273.1 DNA translocase FtsK 4TM domain-containing protein -
N8E86_RS06500 (N8E86_06500) 1387443..1387922 - 480 WP_017806582.1 leucine-responsive transcriptional regulator Lrp -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10833.45 Da        Isoelectric Point: 7.9348

>T259478 WP_264255269.1 NZ_CP104914:1383251-1383529 [Avibacterium paragallinarum]
MITHFTCKDTQAFFEGQRIHRFIPFEKVAMRKLQQLDAATELNFLRIPPGNHLEMLTGDRKGQYSIRINDQWRICFTWLN
GHAADVAIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11127.72 Da        Isoelectric Point: 7.3167

>AT259478 WP_110478985.1 NZ_CP104914:1383539-1383835 [Avibacterium paragallinarum]
MTRQIPLSHPGEILLEEWLKPLGISQYALAKAISVPPRRINEIVKGKRAITPDTALRLATYFGTDPQSWLNLQSHYDTEQ
TRTAINEDLTHISPFQFA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References