Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 844274..844943 Replicon chromosome
Accession NZ_CP104914
Organism Avibacterium paragallinarum strain AG21-0333

Toxin (Protein)


Gene name higB Uniprot ID A0A380X0Q1
Locus tag N8E86_RS04195 Protein ID WP_017807010.1
Coordinates 844274..844639 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8E86_RS04200 Protein ID WP_017807009.1
Coordinates 844641..844943 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E86_RS04175 (N8E86_04175) 839364..840092 + 729 WP_264256736.1 30S ribosomal protein S2 -
N8E86_RS04180 (N8E86_04180) 840224..841069 + 846 WP_264256738.1 translation elongation factor Ts -
N8E86_RS04185 (N8E86_04185) 841394..842983 - 1590 WP_264256741.1 peptide chain release factor 3 -
N8E86_RS04190 (N8E86_04190) 843165..844025 + 861 WP_264256742.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N8E86_RS04195 (N8E86_04195) 844274..844639 + 366 WP_017807010.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N8E86_RS04200 (N8E86_04200) 844641..844943 + 303 WP_017807009.1 XRE family transcriptional regulator Antitoxin
N8E86_RS04205 (N8E86_04205) 845055..845894 + 840 WP_264256743.1 SDR family oxidoreductase -
N8E86_RS04210 (N8E86_04210) 845963..847303 + 1341 WP_264256744.1 argininosuccinate synthase -
N8E86_RS04215 (N8E86_04215) 847419..848294 + 876 WP_264256745.1 VirK/YbjX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14098.33 Da        Isoelectric Point: 4.9436

>T259477 WP_017807010.1 NZ_CP104914:844274-844639 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Download         Length: 366 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11238.21 Da        Isoelectric Point: 9.5655

>AT259477 WP_017807009.1 NZ_CP104914:844641-844943 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380X0Q1

Antitoxin

Source ID Structure

References