Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5242254..5242849 Replicon chromosome
Accession NZ_CP104913
Organism Pseudomonas aeruginosa strain PA-AUTBAM

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag N2X48_RS24290 Protein ID WP_003113526.1
Coordinates 5242571..5242849 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2X48_RS24285 Protein ID WP_003113527.1
Coordinates 5242254..5242559 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X48_RS24250 (N2X48_24250) 5237393..5238241 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
N2X48_RS24260 (N2X48_24260) 5238408..5239349 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
N2X48_RS24265 (N2X48_24265) 5239466..5240080 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
N2X48_RS24270 (N2X48_24270) 5240122..5240706 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
N2X48_RS24275 (N2X48_24275) 5240747..5241847 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
N2X48_RS24285 (N2X48_24285) 5242254..5242559 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
N2X48_RS24290 (N2X48_24290) 5242571..5242849 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2X48_RS24295 (N2X48_24295) 5242902..5243030 - 129 Protein_4797 integrase -
N2X48_RS24300 (N2X48_24300) 5243178..5245406 + 2229 WP_003113525.1 TonB-dependent receptor -
N2X48_RS24305 (N2X48_24305) 5245476..5246123 - 648 WP_003095021.1 carbonate dehydratase -
N2X48_RS24310 (N2X48_24310) 5246185..5247423 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T259476 WP_003113526.1 NZ_CP104913:c5242849-5242571 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT259476 WP_003113527.1 NZ_CP104913:c5242559-5242254 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References